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11-Jul-2020 17:09

The impact of sex on outcome has received little attention in adult CHD compared with acquired cardiovascular disease, in which differences in presentation and prognosis have led to a clinical approach tailored towards the sexes.However, data concerning the impact of sex on long-term morbidity and survival of adults with specific CHD lesions, such as ASD2, is lacking.Patients are recruited by a team of research nurses, through the treating cardiologist or a nationwide media campaign. The database is actively updated, and new clinical events recorded from medical letters are added to the database.The study included all patients registered in CONCOR on June 26 2014, with either ‘ASD within oval fossa (secundum)’ or ‘ASD’ as the primary diagnosis.The CONCOR Dutch national registry for adult CHD patients was initiated in 2001 to facilitate research into the aetiology, prevalence, and outcome of CHD.All adults (≥18 years) with structural congenital heart defects are eligible for inclusion.Median survival was 79.7 years for men and 85.6 years for women with ASD2.Compared with the age- and sex-matched general population, survival was lower for male, but equal for female patients ( = 0.015 and 0.766, respectively).

This cohort had the same sex distribution as the patients in the ASD2 patient cohort (33% male) and followed the gender-specific distribution of age at inclusion observed in the patient cohort (thus following a similar left-truncation pattern, see ).Ventricular dysrhythmias comprised ventricular flutter, ventricular fibrillation, sustained tachycardias, and cardiac arrest.Supraventricular tachydysrhythmias comprised atrial fibrillation, atrial flutter, paroxysmal atrial tachycardia, atrioventricular nodal re-entry tachycardia, and atrioventricular junctional tachycardia.Conduction disturbances include sick sinus syndrome, sinoatrial block, atrioventricular block, and complete left/right bundle branch block.